Anyone else find your jet lag is worst on day 2?

I travel to Europe from the U.S. a couple of times a year and peak jet lag inevitably hits on the second full day. I’m exhausted, irrational and weepy from lack of sleep and the time difference. I get horrible, non-specific anxiety attacks. My stomach is a mess with a mixed bag of nausea, constipation and diarrhea. Does this happen to anyone else? How do you cope?