Trailrunning with Heavy Camera/Telephoto

Hey this might sound dumb but.. I like doing wildlife photography and the bulk of my time spent in the actual wilderness is while trail running.

I want to be able to run and have my Nikon D500 and Tamron 150-600 Telephoto lens with me so I can kinda have the best of both worlds but it's obviously such a bulky thing to run with.

Is this something somebody has done in the past? Or should I just let my dreams be dreams in this case?