Best standalone hotel

I’m normally one of those people who travel somewhere and barely spends anytime at their hotel. I.E. Disney world, Chicago (going to view museums), etc. lately I’ve been craving a getaway where I do not have to leave the hotel. I’m wanting to keep this within the USA because I’m not wanting to fly out of the country and then just stay in the hotel. Bonus point if your rec is in the Midwest but I’m okay with traveling anywhere within the United States. I’m considering all inclusive but am open to all options. Thanks!!